| Host: | Rabbit |
| Applications: | WB/IHC-P/ICC/IF/ChIP/FC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-GATA3 (1-220 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunocytochemistry, Immunofluorescence, ChImmunoprecipitation and Flow Cytometry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | R03-7H8 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS pH7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol. |
| Purification: | Affinity Chromatography |
| Concentration: | - |
| Dilution Range: | WB 1:500-1:1000 IHC 1:50-1:100 IF 1:50-1:200 FC 1:50-1:100 ChIP 1:20 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | GATA3 |
| Gene ID: | 2625 |
| Uniprot ID: | GATA3_HUMAN |
| Immunogen Region: | 1-220 aa |
| Immunogen: | A synthesized peptide derived from human GATA3 |
| Tissue Specificity | T-cells and endothelial cells. |
| Function | Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression. Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. |
| Protein Name | Trans-Acting T-Cell-Specific Transcription Factor Gata-3 Gata-Binding Factor 3 |
| Database Links | Reactome: R-HSA-5689880 Reactome: R-HSA-6785807 Reactome: R-HSA-8939236 Reactome: R-HSA-9018519 Reactome: R-HSA-9830364 Reactome: R-HSA-983231 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Trans-Acting T-Cell-Specific Transcription Factor Gata-3 antibody Anti-Gata-Binding Factor 3 antibody Anti-GATA3 antibody |
Information sourced from Uniprot.org