Anti-GAS6 antibody [SAA0476] {PerCP} (STJA0030533)

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STJA0030533
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Host: Mouse
Applications: ELISA/FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Growth Arrest-Specific Protein 6 is suitable for use in ELISA and Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : SAA0476
Conjugation: PerCP
Isotype: IgG1
Formulation: 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Purification: Purified
Concentration: 0.5 mg/mL
Storage Instruction: Store at 4°C for 12 months. Protect from light. Do not freeze.
Gene Symbol: GAS6
Gene ID: 2621
Uniprot ID: GAS6_HUMAN
Post Translational Modifications Isoform 2: Proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL. Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
Function Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. (Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry. Plays a role in Dengue cell entry by apoptotic mimicry. Plays a role in Vaccinia virus cell entry by apoptotic mimicry. Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry.
Protein Name Growth Arrest-Specific Protein 6
Gas-6
Axl Receptor Tyrosine Kinase Ligand
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-159740
Reactome: R-HSA-159763
Reactome: R-HSA-159782
Reactome: R-HSA-202733
Reactome: R-HSA-381426
Reactome: R-HSA-8957275
Cellular Localisation Secreted
Alternative Antibody Names Anti-Growth Arrest-Specific Protein 6 antibody
Anti-Gas-6 antibody
Anti-Axl Receptor Tyrosine Kinase Ligand antibody
Anti-GAS6 antibody
Anti-AXLLG antibody

Information sourced from Uniprot.org