Anti-GARS antibody (43-289aa) [AT4E10] (STJA0041698)

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STJA0041698
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Host: Mouse
Applications: ELISA/WB/ICC/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal anti-GARS (43-289aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : AT4E10
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol
Purification: By protein-A affinity chromatography
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: GARS1
Gene ID: 2617
Uniprot ID: GARS_HUMAN
Immunogen Region: 43-289aa
Accession Number: NP_002038
Immunogen: Recombinant human GARS (43-289aa) purified from E. coli
Tissue Specificity Widely expressed, including in brain and spinal cord. Isoform 2: Expressed in brain, spinal cord, muscle, heart and spleen. Isoform 1: Expressed in brain, spinal cord, muscle, heart, spleen and liver.
Function Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.
Protein Name Glycine--Trna Ligase
Diadenosine Tetraphosphate Synthetase
Ap4a Synthetase
Glycyl-Trna Synthetase
Glyrs
Glycyl-Trna Synthetase 1
Database Links Reactome: R-HSA-379716
Reactome: R-HSA-379726
Cellular Localisation Cytoplasm
Cell Projection
Axon
Secreted
Extracellular Exosome
In Transfected Cos7 Cells
Not Detected In Mitochondria
Nor In Golgi Apparatus
Secreted By Motor Neuron
Possibly Through The Exosome Pathway
Isoform 1: Mitochondrion
Isoform 2: Cytoplasm
Alternative Antibody Names Anti-Glycine--Trna Ligase antibody
Anti-Diadenosine Tetraphosphate Synthetase antibody
Anti-Ap4a Synthetase antibody
Anti-Glycyl-Trna Synthetase antibody
Anti-Glyrs antibody
Anti-Glycyl-Trna Synthetase 1 antibody
Anti-GARS1 antibody
Anti-GARS antibody

Information sourced from Uniprot.org

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