| Host: | Rabbit |
| Applications: | WB/IHC-P/ICC/IF/FC |
| Reactivity: | Human/Mouse/Rat/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal anti-gamma Catenin for use in WB, IHC-P, ICC, IF and FC in Human, Mouse, Rat and Dog samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | R01-3P1 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification: | Affinity Chromatography |
| Dilution Range: | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200FC 1:50-1:100 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | JUP |
| Gene ID: | 3728 |
| Uniprot ID: | PLAK_HUMAN |
| Immunogen: | A synthesized peptide derived from human Catenin gamma |
| Tissue Specificity | Expressed in the heart (at protein level). |
| Post Translational Modifications | May be phosphorylated by FER. |
| Function | Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. |
| Protein Name | Junction PlakoglobinCatenin GammaDesmoplakin IiiDesmoplakin-3 |
| Database Links | Reactome: R-HSA-418990Reactome: R-HSA-5218920Reactome: R-HSA-6798695Reactome: R-HSA-6805567Reactome: R-HSA-6809371Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013406Reactome: R-HSA-9013407Reactome: R-HSA-9013409Reactome: R-HSA-9762292Reactome: R-HSA-9764302Reactome: R-HSA-9833576 |
| Cellular Localisation | Cell JunctionAdherens JunctionDesmosomeCytoplasmCytoskeletonCell MembranePeripheral Membrane ProteinNucleusCytoplasmic In A Soluble And Membrane-Associated FormColocalizes With Dsg4 At Desmosomes |
| Alternative Antibody Names | Anti-Junction Plakoglobin antibodyAnti-Catenin Gamma antibodyAnti-Desmoplakin Iii antibodyAnti-Desmoplakin-3 antibodyAnti-JUP antibodyAnti-CTNNG antibodyAnti-DP3 antibody |
Information sourced from Uniprot.org