| Host: | Rabbit |
| Applications: | WB/IHC-P/ICC/IF/IP/FC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal anti-Galectin 8 for use in WB, IHC-P, ICC, IF, IP and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | R03-4O9 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification: | Affinity Chromatography |
| Dilution Range: | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200IP 1:50FC 1:50-1:100 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | LGALS8 |
| Gene ID: | 3964 |
| Uniprot ID: | LEG8_HUMAN |
| Immunogen: | A synthesized peptide derived from human Galectin 8 |
| Tissue Specificity | Ubiquitous. Selective expression by prostate carcinomas versus normal prostate and benign prostatic hypertrophy. |
| Function | Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane.these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans. |
| Protein Name | Galectin-8Gal-8Po66 Carbohydrate-Binding ProteinPo66-CbpProstate Carcinoma Tumor Antigen 1Pcta-1 |
| Database Links | |
| Cellular Localisation | Cytoplasmic VesicleCytoplasmCytosol |
| Alternative Antibody Names | Anti-Galectin-8 antibodyAnti-Gal-8 antibodyAnti-Po66 Carbohydrate-Binding Protein antibodyAnti-Po66-Cbp antibodyAnti-Prostate Carcinoma Tumor Antigen 1 antibodyAnti-Pcta-1 antibodyAnti-LGALS8 antibody |
Information sourced from Uniprot.org