| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Gamma-aminobutyric acid receptor subunit pi receptor subunit pi (181-231 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GABRP |
| Gene ID: |
2568 |
| Uniprot ID: |
GBRP_HUMAN |
| Immunogen Region: |
181-231 aa |
| Specificity: |
This antibody detects endogenous levels of human GBRP |
| Immunogen: |
Synthesized peptide derived from the human GBRP at the amino acid range 181-231 |
| Function | Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces. When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Pi-containing GABAARs are mostly located in peripheral tissues. In the uterus, pi subunits modulate uterus contraction by altering the sensitivity of GABAARs to pregnanolone. In the lungs, pi-containing GABAARs contribute to pulmonary fluid transport via luminal secretion of chloride. |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit PiGaba(A Receptor Subunit PiGabaar Subunit Pi |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneLocated On The Apical Plasma Membrane Of Alveolar Epithelial Type Ii Cells |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Pi antibodyAnti-Gaba(A Receptor Subunit Pi antibodyAnti-Gabaar Subunit Pi antibodyAnti-GABRP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
