| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
GABRA1 |
| Gene ID: |
2554 |
| Uniprot ID: |
GBRA1_HUMAN |
| Immunogen Region: |
28-251 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 28-251 of human GABRA1 (NP_000797.2). |
| Immunogen Sequence: |
QPSLQDELKDNTTVFTRILD RLLDGYDNRLRPGLGERVTE VKTDIFVTSFGPVSDHDMEY TIDVFFRQSWKDERLKFKGP MTVLRLNNLMASKIWTPDTF FHNGKKSVAHNMTMPNKLLR ITEDGTLLYTMRLTVRAECP MHLEDFPMDAHACPLKFGSY AYTRAEVVYEWTREPARSVV VAEDGSRLNQYDLLGQTVDS GIVQSSTGEYVVMTTHFHLK RKIG |
| Function | Alpha subunit of the heteropentameric ligand-gated chloride channel gated by Gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Alpha-1/GABRA1-containing GABAARs are largely synaptic. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity.the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation. GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response. GABAARs containing alpha, beta and epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings. Alpha-1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection. Together with rho subunits, may also control neuronal and glial GABAergic transmission in the cerebellum. |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit Alpha-1Gaba(A Receptor Subunit Alpha-1Gabaar Subunit Alpha-1 |
| Database Links | Reactome: R-HSA-1236394Reactome: R-HSA-977443 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmic Vesicle MembraneMainly Located In Gabaergic Synapses In Granule CellsAnd Also In The Extrasynaptic Membrane At A Lower Concentration |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Alpha-1 antibodyAnti-Gaba(A Receptor Subunit Alpha-1 antibodyAnti-Gabaar Subunit Alpha-1 antibodyAnti-GABRA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
