Anti-GAB2 antibody (Internal) (STJ71161)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-GAB2 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 80kDa band observed in lysates of cell line K562 (calculated MW of 74.5kDa according to NP_536739.1). Recommended concentration: 0.5-1.5ยตg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | GAB2 |
| Gene ID | 9846 |
| Uniprot ID | GAB2_HUMAN |
| Accession Number | NP_536739.1; NP_036428.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | QVDKEKTQALQN |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_536739.1; NP_036428.1). |
Additional Info
| Function | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. |
| Protein Name | Grb2-Associated-Binding Protein 2Grb2-Associated Binder 2Growth Factor Receptor Bound Protein 2-Associated Protein 2Pp100 |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1257604Reactome: R-HSA-1433557Reactome: R-HSA-1839117Reactome: R-HSA-2219530Reactome: R-HSA-2730905Reactome: R-HSA-6811558Reactome: R-HSA-8853659Reactome: R-HSA-8983432Reactome: R-HSA-912526Reactome: R-HSA-9607240Reactome: R-HSA-9645135Reactome: R-HSA-9674555Reactome: R-HSA-9680350Reactome: R-HSA-9702518Reactome: R-HSA-9703465Reactome: R-HSA-9703648 |
| Cellular Localisation | CytoplasmCell MembraneMembrane Raft |
| Alternative Antibody Names | Anti-Grb2-Associated-Binding Protein 2 antibodyAnti-Grb2-Associated Binder 2 antibodyAnti-Growth Factor Receptor Bound Protein 2-Associated Protein 2 antibodyAnti-Pp100 antibodyAnti-GAB2 antibodyAnti-KIAA0571 antibody |
Information sourced from Uniprot.org