| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | G6PD |
| Gene ID: | 2539 |
| Uniprot ID: | G6PD_HUMAN |
| Immunogen Region: | 195-515 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 195-515 of human G6PD (NP_001035810.1). |
| Immunogen Sequence: | QIYRIDHYLGKEMVQNLMVL RFANRIFGPIWNRDNIACVI LTFKEPFGTEGRGGYFDEFG IIRDVMQNHLLQMLCLVAME KPASTNSDDVRDEKVKVLKC ISEVQANNVVLGQYVGNPDG EGEATKGYLDDPTVPRGSTT ATFAAVVLYVENERWDGVPF ILRCGKALNERKAEVRLQFH DVAGDIFHQQCKRNELVIRV QPNEAVYTKMMTKKPGMFFN PEESELDLTYGNRYKNVKL |
| Tissue Specificity | Isoform Long is found in lymphoblasts, granulocytes and sperm. |
| Post Translational Modifications | Acetylated by ELP3 at Lys-403.acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2 at Lys-403.deacetylation stimulates its enzyme activity. |
| Function | Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. |
| Protein Name | Glucose-6-Phosphate 1-DehydrogenaseG6pd |
| Database Links | Reactome: R-HSA-5628897Reactome: R-HSA-71336Reactome: R-HSA-9818028 |
| Cellular Localisation | CytoplasmCytosolMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Glucose-6-Phosphate 1-Dehydrogenase antibodyAnti-G6pd antibodyAnti-G6PD antibody |
Information sourced from Uniprot.org