Anti-FZD9 antibody (C-Term) (STJ71552)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-FZD9 (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.IHC: Paraffin embedded Human Testis and Thyroid. Recommended concentration: 5ยตg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | FZD9 |
| Gene ID | 8326 |
| Uniprot ID | FZD9_HUMAN |
| Accession Number | NP_003499.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | TKTDPSLENPTH |
Additional Info
| Post Translational Modifications | Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. |
| Function | Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway. May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process. During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling. |
| Protein Name | Frizzled-9Fz-9Hfz9Fze6Cd Antigen Cd349 |
| Database Links | Reactome: R-HSA-373080 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinRelocalizes Dvl1 To The Cell Membrane Leading To Phosphorylation Of Dvl1 And Axin1 Relocalization To The Cell Membrane |
| Alternative Antibody Names | Anti-Frizzled-9 antibodyAnti-Fz-9 antibodyAnti-Hfz9 antibodyAnti-Fze6 antibodyAnti-Cd Antigen Cd349 antibodyAnti-FZD9 antibodyAnti-FZD3 antibody |
Information sourced from Uniprot.org