Anti-FZD5 antibody (461-510 aa) (STJ93146)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human FZD5 at the amino acid range 461-510
General Information
| Short Description | Rabbit polyclonal anti-Frizzled-5 (461-510 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FZD5 |
| Gene ID | 7855 |
| Uniprot ID | FZD5_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human FZD5 at the amino acid range 461-510 |
| Immunogen Region | 461-510 aa |
| Specificity | Frizzled-5 Polyclonal Antibody detects endogenous levels of Frizzled-5 protein. |
Additional Info
| Function | Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling. In neurons, activation by WNT7A promotes formation of synapses. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization. Plays a role in ocular development. |
| Protein Name | Frizzled-5Fz-5Hfz5Fze5 |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-4086398Reactome: R-HSA-4608870Reactome: R-HSA-4641262Reactome: R-HSA-4641263Reactome: R-HSA-5140745Reactome: R-HSA-5340588 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneSynapsePerikaryonCell ProjectionDendriteAxonLocalized At The Plasma Membrane And Also Found At The Golgi Apparatus |
| Alternative Antibody Names | Anti-Frizzled-5 antibodyAnti-Fz-5 antibodyAnti-Hfz5 antibodyAnti-Fze5 antibodyAnti-FZD5 antibodyAnti-C2orf31 antibody |
Information sourced from Uniprot.org