| Post Translational Modifications | Major plasma membrane substrate for cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation. Phosphorylation at Ser-88 stimulates sodium/potassium-transporting ATPase activity while the unphosphorylated form inhibits sodium/potassium-transporting ATPase activity. Phosphorylation increases tetramerization, decreases binding to ATP1A1 and reduces inhibition of ATP1A1 activity. Phosphorylation at Ser-83 leads to greatly reduced interaction with ATP1A1, ATP1A2 and ATP1A3. May be phosphorylated by DMPK. Palmitoylation increases half-life and stability and is enhanced upon phosphorylation at Ser-88 by PKA. |
| Function | Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. |
| Protein Name | PhospholemmanFxyd Domain-Containing Ion Transport Regulator 1Sodium/Potassium-Transporting Atpase Subunit Fxyd1 |
| Database Links | Reactome: R-HSA-5578775Reactome: R-HSA-936837Reactome: R-HSA-9679191 |
| Cellular Localisation | Cell MembraneSarcolemmaSingle-Pass Type I Membrane ProteinApical Cell MembraneMembraneCaveolaT-TubuleDetected In The Apical Cell Membrane In BrainIn MyocytesLocalizes To SarcolemmaT-Tubules And Intercalated Disks |
| Alternative Antibody Names | Anti-Phospholemman antibodyAnti-Fxyd Domain-Containing Ion Transport Regulator 1 antibodyAnti-Sodium/Potassium-Transporting Atpase Subunit Fxyd1 antibodyAnti-FXYD1 antibodyAnti-PLM antibody |
Information sourced from Uniprot.org
