| Function | Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1. Attaches fucose through an O-glycosidic linkage. O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion. May also show alpha-(1,3)-fucosyltransferase activity toward the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. However, this was tested with a library of synthetic substrates and this activity is unsure in vivo. May be involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development. |
| Protein Name | Gdp-Fucose Protein O-Fucosyltransferase 3Alpha-(1 -3-Fucosyltransferase 10Fucosyltransferase XFuc-TxFuct-XGalactoside 3-L-Fucosyltransferase 10Fucosyltransferase 10 |
| Database Links | Reactome: R-HSA-9037629 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane ProteinIsoform 1: Endoplasmic Reticulum MembraneGolgi Apparatus MembraneIsoform 4: Golgi ApparatusLysosomeIsoform 5: Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Gdp-Fucose Protein O-Fucosyltransferase 3 antibodyAnti-Alpha-(1 -3-Fucosyltransferase 10 antibodyAnti-Fucosyltransferase X antibodyAnti-Fuc-Tx antibodyAnti-Fuct-X antibodyAnti-Galactoside 3-L-Fucosyltransferase 10 antibodyAnti-Fucosyltransferase 10 antibodyAnti-FUT10 antibodyAnti-POFUT3 antibody |
Information sourced from Uniprot.org
