Anti-Fukutin antibody (362-461) [S6MR] (STJ11102756)

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STJ11102756
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Host: Rabbit
Applications: WB/IHC-P/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : S6MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IHC-P:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FKTN
Gene ID: 2218
Uniprot ID: FKTN_HUMAN
Immunogen Region: 362-461
Specificity: A synthetic peptide corresponding to a sequence within amino acids 362-461 of human Fukutin (O75072).
Immunogen Sequence: DVKLDVFFFYEETDHMWNGG TQAKTGKKFKYLFPKFTLCW TEFVDMKVHVPCETLEYIEA NYGKTWKIPVKTWDWKRSPP NVQPNGIWPISEWDEVIQLY
Tissue Specificity Expressed in the retina (at protein level). Widely expressed with highest expression in brain, heart, pancreas and skeletal muscle. Expressed at similar levels in control fetal and adult brain. Expressed in migrating neurons, including Cajar-Retzius cells and adult cortical neurons, as well as hippocampal pyramidal cells and cerebellar Purkinje cells. No expression observed in the glia limitans, the subpial astrocytes (which contribute to basement membrane formation) or other glial cells.
Function Catalyzes the transfer of a ribitol-phosphate from CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1. Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity. May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes. Could be involved in brain development (Probable).
Protein Name Ribitol-5-Phosphate Transferase Fktn
Fukutin
Fukuyama-Type Congenital Muscular Dystrophy Protein
Ribitol-5-Phosphate Transferase
Cellular Localisation Golgi Apparatus Membrane
Single-Pass Type Ii Membrane Protein
Cytoplasm
Nucleus
In Retinal Tissue
Does Not Localize With The Golgi Apparatus
Alternative Antibody Names Anti-Ribitol-5-Phosphate Transferase Fktn antibody
Anti-Fukutin antibody
Anti-Fukuyama-Type Congenital Muscular Dystrophy Protein antibody
Anti-Ribitol-5-Phosphate Transferase antibody
Anti-FKTN antibody
Anti-FCMD antibody

Information sourced from Uniprot.org