Anti-FRK antibody (71-120 aa) (STJ95361)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human FRK at the amino acid range 71-120
General Information
| Short Description | Rabbit polyclonal anti-Tyrosine-protein kinase FRK (71-120 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FRK |
| Gene ID | 2444 |
| Uniprot ID | FRK_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human FRK at the amino acid range 71-120 |
| Immunogen Region | 71-120 aa |
| Specificity | Rak Polyclonal Antibody detects endogenous levels of Rak protein. |
Additional Info
| Function | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. |
| Protein Name | Tyrosine-Protein Kinase FrkFyn-Related KinaseNuclear Tyrosine Protein Kinase RakProtein-Tyrosine Kinase 5 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8948751 |
| Cellular Localisation | CytoplasmNucleusPredominantly Found In The NucleusWith A Small Fraction Found In The Cell Periphery |
| Alternative Antibody Names | Anti-Tyrosine-Protein Kinase Frk antibodyAnti-Fyn-Related Kinase antibodyAnti-Nuclear Tyrosine Protein Kinase Rak antibodyAnti-Protein-Tyrosine Kinase 5 antibodyAnti-FRK antibodyAnti-PTK5 antibodyAnti-RAK antibody |
Information sourced from Uniprot.org