| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Tyrosine-protein kinase FRK (71-120 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FRK |
| Gene ID: | 2444 |
| Uniprot ID: | FRK_HUMAN |
| Immunogen Region: | 71-120 aa |
| Specificity: | Rak Polyclonal Antibody detects endogenous levels of Rak protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human FRK at the amino acid range 71-120 |
| Function | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. |
| Protein Name | Tyrosine-Protein Kinase FrkFyn-Related KinaseNuclear Tyrosine Protein Kinase RakProtein-Tyrosine Kinase 5 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8948751 |
| Cellular Localisation | CytoplasmNucleusPredominantly Found In The NucleusWith A Small Fraction Found In The Cell Periphery |
| Alternative Antibody Names | Anti-Tyrosine-Protein Kinase Frk antibodyAnti-Fyn-Related Kinase antibodyAnti-Nuclear Tyrosine Protein Kinase Rak antibodyAnti-Protein-Tyrosine Kinase 5 antibodyAnti-FRK antibodyAnti-PTK5 antibodyAnti-RAK antibody |
Information sourced from Uniprot.org
