Anti-FPR2 antibody (1-100 aa) (STJ11104999)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal N-Formyl Peptide Receptor 2 (1-100 aa) antibody for use in IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FPR2 |
| Gene ID | 2358 |
| Uniprot ID | FPR2_HUMAN |
| Immunogen Region | 1-100 aa |
| Immunogen Sequence | METNFSTPLNEYEEVSYESA GYTVLRILPLVVLGVTFVLG VLGNGLVIWVAGFRMTRTVT TICYLNLALADFSFTATLPF LIVSMAMGEKWPFGWFLCKL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human FPR2. (NP_001453.1). |
Additional Info
| Tissue Specificity | Detected in lung, bone marrow, neutrophils, spleen and testis. |
| Function | Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of pro-inflammatory signals such as LTB4 (leukotriene B4). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation. Acts as a receptor for humanin. |
| Protein Name | N-Formyl Peptide Receptor 2Fmlp-Related Receptor IFmlp-R-IFormyl Peptide Receptor-Like 1Hm63Lipoxin A4 ReceptorLxa4 ReceptorRfp |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-418594Reactome: R-HSA-444473Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinAssociates With Amyloid-Beta Protein 42Product Of AppAt The Cell Surface And The Complex Is Then Rapidly InternalizedAlso Internalized In The Presence Of Humanin |
| Alternative Antibody Names | Anti-N-Formyl Peptide Receptor 2 antibodyAnti-Fmlp-Related Receptor I antibodyAnti-Fmlp-R-I antibodyAnti-Formyl Peptide Receptor-Like 1 antibodyAnti-Hm63 antibodyAnti-Lipoxin A4 Receptor antibodyAnti-Lxa4 Receptor antibodyAnti-Rfp antibodyAnti-FPR2 antibodyAnti-FPRH1 antibodyAnti-FPRL1 antibodyAnti-LXA4R antibody |
Information sourced from Uniprot.org