Anti-FPR1 antibody (2-50 aa) (STJ13101115)

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STJ13101115-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-FPR1 (2-50 aa) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: FPR1
Gene ID: 2357
Uniprot ID: FPR1_HUMAN
Immunogen Region: 2-50 aa
Specificity: Specific for FPR1.
Immunogen: A synthetic peptide from aa region 2-50 of human FPR1 conjugated to blue carrier protein was used as the antigen.
Post Translational Modifications Phosphorylated.which is necessary for desensitization.
Function High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release. Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis.
Protein Name Fmet-Leu-Phe Receptor
Fmlp Receptor
N-Formyl Peptide Receptor
Fpr
N-Formylpeptide Chemoattractant Receptor
Database Links Reactome: R-HSA-418594
Reactome: R-HSA-444473
Reactome: R-HSA-6783783
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Internalizes In Presence Of Its Ligands
Fmlp
Tafa4 And Ctsg
Alternative Antibody Names Anti-Fmet-Leu-Phe Receptor antibody
Anti-Fmlp Receptor antibody
Anti-N-Formyl Peptide Receptor antibody
Anti-Fpr antibody
Anti-N-Formylpeptide Chemoattractant Receptor antibody
Anti-FPR1 antibody

Information sourced from Uniprot.org

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