| Post Translational Modifications | Sumoylated with SUMO1.sumoylation is required for transcriptional repression activity. |
| Function | Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Is a regulator of CYP19 expression. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element. Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. |
| Protein Name | Forkhead Box Protein L2 |
| Database Links | Reactome: R-HSA-3232118 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Forkhead Box Protein L2 antibodyAnti-FOXL2 antibody |
Information sourced from Uniprot.org
