| Function | Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. |
| Protein Name | Protein C-FosCellular Oncogene FosFos Proto-Oncogene - Ap-1 Transcription Factor SubunitG0/G1 Switch Regulatory Protein 7Proto-Oncogene C-FosTranscription Factor Ap-1 Subunit C-Fos |
| Database Links | Reactome: R-HSA-2559580Reactome: R-HSA-2559582Reactome: R-HSA-2871796Reactome: R-HSA-450341Reactome: R-HSA-6785807Reactome: R-HSA-6796648Reactome: R-HSA-9018519Reactome: R-HSA-9031628Reactome: R-HSA-9634638Reactome: R-HSA-9768919 |
| Cellular Localisation | NucleusEndoplasmic ReticulumCytoplasmCytosolIn Quiescent CellsPresent In Very Small Amounts In The CytosolFollowing Induction Of Cell GrowthFirst Localizes To The Endoplasmic Reticulum And Only Later To The NucleusLocalization At The Endoplasmic Reticulum Requires Dephosphorylation At Tyr-10 And Tyr-30 |
| Alternative Nanobody Names | Anti-Protein C-Fos nanobodyAnti-Cellular Oncogene Fos nanobodyAnti-Fos Proto-Oncogene - Ap-1 Transcription Factor Subunit nanobodyAnti-G0/G1 Switch Regulatory Protein 7 nanobodyAnti-Proto-Oncogene C-Fos nanobodyAnti-Transcription Factor Ap-1 Subunit C-Fos nanobodyAnti-FOS nanobodyAnti-G0S7 nanobody |
Information sourced from Uniprot.org
![Anti-FOS nanobody [SAA1335] (STJN000074)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200687/412869/STJN000074-SDS-PAGE-1__49559.1749232413.jpg?c=1 "Anti-FOS nanobody [SAA1335] (STJN000074)")
![Anti-FOS nanobody [SAA1335] (STJN000074)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200687/412869/STJN000074-SDS-PAGE-1__49559.1749232413.jpg?c=1 "Anti-FOS nanobody [SAA1335] (STJN000074)")
