| Post Translational Modifications | The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis. The N-terminus is blocked. |
| Function | Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. |
| Protein Name | Glutamate Carboxypeptidase 2Cell Growth-Inhibiting Gene 27 ProteinFolate Hydrolase 1Folylpoly-Gamma-Glutamate CarboxypeptidaseFgcpGlutamate Carboxypeptidase IiGcpiiMembrane Glutamate CarboxypeptidaseMgcpN-Acetylated-Alpha-Linked Acidic Dipeptidase INaaladase IProstate-Specific Membrane AntigenPsmPsmaPteroylpoly-Gamma-Glutamate Carboxypeptidase |
| Database Links | Reactome: R-HSA-8963693 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinIsoform Psma': Cytoplasm |
| Alternative Nanobody Names | Anti-Glutamate Carboxypeptidase 2 nanobodyAnti-Cell Growth-Inhibiting Gene 27 Protein nanobodyAnti-Folate Hydrolase 1 nanobodyAnti-Folylpoly-Gamma-Glutamate Carboxypeptidase nanobodyAnti-Fgcp nanobodyAnti-Glutamate Carboxypeptidase Ii nanobodyAnti-Gcpii nanobodyAnti-Membrane Glutamate Carboxypeptidase nanobodyAnti-Mgcp nanobodyAnti-N-Acetylated-Alpha-Linked Acidic Dipeptidase I nanobodyAnti-Naaladase I nanobodyAnti-Prostate-Specific Membrane Antigen nanobodyAnti-Psm nanobodyAnti-Psma nanobodyAnti-Pteroylpoly-Gamma-Glutamate Carboxypeptidase nanobodyAnti-FOLH1 nanobodyAnti-FOLH nanobodyAnti-NAALAD1 nanobodyAnti-PSM nanobodyAnti-PSMA nanobodyAnti-GIG27 nanobody |
Information sourced from Uniprot.org
![Anti-FOLH1/PSMA nanobody [SAA1352] (STJN000256)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200869/413051/STJN000256-SDS-PAGE-1__86787.1749232562.jpg?c=1 "Anti-FOLH1/PSMA nanobody [SAA1352] (STJN000256)")
![Anti-FOLH1/PSMA nanobody [SAA1352] (STJN000256)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200869/413051/STJN000256-SDS-PAGE-1__86787.1749232562.jpg?c=1 "Anti-FOLH1/PSMA nanobody [SAA1352] (STJN000256)")
