| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | FOLR1 |
| Gene ID: | 2348 |
| Uniprot ID: | FOLR1_HUMAN |
| Immunogen Region: | 1-100 aa |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Folate Binding Protein (FBP) /FOLR1 (NP_000793.1). |
| Immunogen Sequence: | MAQRMTTQLLLLLVWVAVVG EAQTRIAWARTELLNVCMNA KHHKEKPGPEDKLHEQCRPW RKNACCSTNTSQEAHKDVSY LYRFNWNHCGEMAPACKRHF |
| Tissue Specificity | Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium. |
| Post Translational Modifications | The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. |
| Protein Name | Folate Receptor Alpha Fr-Alpha Adult Folate-Binding Protein Fbp Folate Receptor 1 Folate Receptor - Adult Kb Cells Fbp Ovarian Tumor-Associated Antigen Mov18 |
| Database Links | Reactome: R-HSA-204005 Reactome: R-HSA-5694530 Reactome: R-HSA-6807878 |
| Cellular Localisation | Cell Membrane Lipid-Anchor Gpi-Anchor Apical Cell Membrane Basolateral Cell Membrane Gpi-Like-Anchor Secreted Cytoplasmic Vesicle Clathrin-Coated Vesicle Endosome Endocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane |
| Alternative Antibody Names | Anti-Folate Receptor Alpha antibody Anti-Fr-Alpha antibody Anti-Adult Folate-Binding Protein antibody Anti-Fbp antibody Anti-Folate Receptor 1 antibody Anti-Folate Receptor - Adult antibody Anti-Kb Cells Fbp antibody Anti-Ovarian Tumor-Associated Antigen Mov18 antibody Anti-FOLR1 antibody Anti-FOLR antibody |
Information sourced from Uniprot.org