| Post Translational Modifications | Phosphorylated by AMPK. |
| Function | Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3. Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling. In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3. Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3. Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy. In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90. Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions. |
| Protein Name | Folliculin-Interacting Protein 2Fnip1-Like ProteinO6-Methylguanine-Induced Apoptosis 1 Protein |
| Database Links | Reactome: R-HSA-9639288 |
| Cellular Localisation | Lysosome MembraneCytoplasmColocalizes With Flcn In The Cytoplasm |
| Alternative Antibody Names | Anti-Folliculin-Interacting Protein 2 antibodyAnti-Fnip1-Like Protein antibodyAnti-O6-Methylguanine-Induced Apoptosis 1 Protein antibodyAnti-FNIP2 antibodyAnti-FNIPL antibodyAnti-KIAA1450 antibodyAnti-MAPO1 antibody |
Information sourced from Uniprot.org
