• Immunohistochemistry analysis of FNDC4 in paraffin-embedded mouse spleen using FNDC4 Rabbit polyclonal antibody (STJ119795) at dilution of 1:150 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of FNDC4 in paraffin-embedded human colon using FNDC4 Rabbit polyclonal antibody (STJ119795) at dilution of 1:150 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.

Anti-FNDC4 antibody (45-167) (STJ119795)

SKU:
STJ119795

£112.50 - £522.50
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Host: Rabbit
Applications: IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FNDC4 (45-167) is suitable for use in Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC-P 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FNDC4
Gene ID: 64838
Uniprot ID: FNDC4_HUMAN
Immunogen Region: 45-167
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 45-167 of human FNDC4 (NP_073734.1).
Immunogen Sequence: DRPPSPVNVTVTHLRANSAT VSWDVPEGNIVIGYSISQQR QNGPGQRVIREVNTTTRACA LWGLAEDSDYTVQVRSIGLR GESPPGPRVHFRTLKGSDRL PSNSSSPGDITVEGLDGERP LQT
Tissue Specificity Up-regulated in colon cells of patients with inflammatory bowel disease (IBD).
Function Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to down-regulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by down-regulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis.
Protein Name Fibronectin Type Iii Domain-Containing Protein 4
Fibronectin Type Iii Repeat-Containing Protein 1
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Secreted
The N-Terminus Is Probably Cleaved To Release A Secreted Extracellular Portion Of The Protein
Alternative Antibody Names Anti-Fibronectin Type Iii Domain-Containing Protein 4 antibody
Anti-Fibronectin Type Iii Repeat-Containing Protein 1 antibody
Anti-FNDC4 antibody
Anti-FRCP1 antibody
Anti-UNQ6389 antibody
Anti-PRO21134 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance