Anti-FMO3 antibody (300-400) [S5MR] (STJ11102955)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal FMO3 (300-400) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FMO3 |
| Gene ID | 2328 |
| Uniprot ID | FMO3_HUMAN |
| Immunogen Region | 300-400 |
| Immunogen Sequence | KPNVKEFTETSAIFEDGTIF EGIDCVIFATGYSFAYPFLD ESIIKSRNNEIILFKGVFPP LLEKSTIAVIGFVQSLGAAI PTVDLQSRWAAQVIKGTCTL P |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human FMO3 (P31513). |
Additional Info
| Tissue Specificity | Liver. |
| Function | Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation. |
| Protein Name | Flavin-Containing Monooxygenase 3 Dimethylaniline Monooxygenase N-Oxide-Forming 3Dimethylaniline Oxidase 3Fmo IiFmo Form 2Hepatic Flavin-Containing Monooxygenase 3Fmo 3Trimethylamine Monooxygenase |
| Database Links | Reactome: R-HSA-217271Reactome: R-HSA-5579019 |
| Cellular Localisation | Microsome MembraneSingle-Pass Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Flavin-Containing Monooxygenase 3 antibodyAnti-Dimethylaniline Monooxygenase N-Oxide-Forming 3 antibodyAnti-Dimethylaniline Oxidase 3 antibodyAnti-Fmo Ii antibodyAnti-Fmo Form 2 antibodyAnti-Hepatic Flavin-Containing Monooxygenase 3 antibodyAnti-Fmo 3 antibodyAnti-Trimethylamine Monooxygenase antibodyAnti-FMO3 antibody |
Information sourced from Uniprot.org