| Function | Choline uniporter that specifically mediates choline uptake at the blood-brain-barrier. Responsible for the majority of choline uptake across the blood-brain-barrier from the circulation into the brain. Choline, a nutrient critical for brain development, is a precursor of phosphatidylcholine, as well as betaine. Also mediates transport of ethanolamine. Choline and ethanolamine transport is not coupled with proton transport and is exclusively driven by the choline gradient across the plasma membrane. However, the presence of an inwardly directed proton gradient enhances choline uptake. Also acts as a heme b transporter. Required to regulate mitochondrial respiration processes, ATP synthesis and thermogenesis. At low heme levels, interacts with components of electron transfer chain (ETC) complexes and ATP2A2, leading to ubiquitin-mediated degradation of ATP2A2 and inhibition of thermogenesis. Upon heme binding, dissociates from ETC complexes to allow switching from mitochondrial ATP synthesis to thermogenesis. |
| Protein Name | Choline/Ethanolamine Transporter Flvcr2Calcium-Chelate TransporterCctFeline Leukemia Virus Subgroup C Receptor-Related Protein 2Heme Transporter Flvcr2 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMitochondrion MembraneEndoplasmic Reticulum MembranePresent On Both Luminal (Blood-Facing) And Abluminal (Brain-Facing) Sides Of Brain Endothelial Cell Plasma MembranesWith Higher Luminal Membrane ExpressionAlso Localizes In Mitochondria Where It Interacts With Components Of The Electron Transfer Complexes IiiIv And VColocalizes With Atp2a2 At The Mitochondrial-Er Contact Junction |
| Alternative Antibody Names | Anti-Choline/Ethanolamine Transporter Flvcr2 antibodyAnti-Calcium-Chelate Transporter antibodyAnti-Cct antibodyAnti-Feline Leukemia Virus Subgroup C Receptor-Related Protein 2 antibodyAnti-Heme Transporter Flvcr2 antibodyAnti-FLVCR2 antibodyAnti-C14orf58 antibody |
Information sourced from Uniprot.org
