| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FLVCR2 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FLVCR2 |
| Gene ID: |
55640 |
| Uniprot ID: |
FLVC2_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human FLVCR2 (NP_060261.2). |
| Immunogen Sequence: |
MVNEGPNQEESDDTPVPESA LQADPSVSVHPSVSVHPSVS INPSVSVHPSSSAHPSALAQ PSGLAHPSSSGPEDLSVIKV SRRRWAVVLVFSCYSMCNSF |
| Tissue Specificity | Expressed in non-hematopoietic tissues, with relative abundant expression in brain, placenta, lung, liver and kidney. Also expressed in hematopoietic tissues (fetal liver, spleen, lymph node, thymus, leukocytes and bone marrow). Found in acidophil cells of the pituitary that secrete growth hormone and prolactin (at protein level). |
| Function | Putative heme b importer/sensor involved in heme homeostasis in response to the metabolic state of the cell and to diet. May act as a sensor of cytosolic and/or mitochondrial heme levels to regulate mitochondrial respiration processes, ATP synthesis and thermogenesis. At low heme levels, interacts with components of electron transfer chain (ETC) complexes and ATP2A2, leading to ubiquitin-mediated degradation of ATP2A2 and inhibition of thermogenesis. Upon heme binding, dissociates from ETC complexes to allow switching from mitochondrial ATP synthesis to thermogenesis. Alternatively, in coordination with ATP2A2 may mediate calcium transport and signaling in response to heme. |
| Protein Name | Heme Transporter Flvcr2Calcium-Chelate TransporterCctFeline Leukemia Virus Subgroup C Receptor-Related Protein 2 |
| Cellular Localisation | Mitochondrion MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneCell MembranePrimarily Resides In Mitochondria Where It Interacts With Components Of The Electron Transfer Chain Complexes IiiIv And VColocalizes With Atp2a2 At The Mitochondrial-Er Contact Junction |
| Alternative Antibody Names | Anti-Heme Transporter Flvcr2 antibodyAnti-Calcium-Chelate Transporter antibodyAnti-Cct antibodyAnti-Feline Leukemia Virus Subgroup C Receptor-Related Protein 2 antibodyAnti-FLVCR2 antibodyAnti-C14orf58 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
