Anti-FLT3 antibody (900-950) {Biotin} (STJ501068)

SKU:
STJ501068-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FLT3 (900-950) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:2, 500-1:5, 000
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: FLT3
Gene ID: 2322
Uniprot ID: FLT3_HUMAN
Immunogen Region: 900-950
Immunogen: Synthetic peptide taken within amino acid region 900-950 on human Receptor-type tyrosine-protein kinase FLT3 protein.
Post Translational Modifications N-glycosylated, contains complex N-glycans with sialic acid. Autophosphorylated on several tyrosine residues in response to FLT3LG binding. FLT3LG binding also increases phosphorylation of mutant kinases that are constitutively activated. Dephosphorylated by PTPRJ/DEP-1, PTPN1, PTPN6/SHP-1, and to a lesser degree by PTPN12. Dephosphorylation is important for export from the endoplasmic reticulum and location at the cell membrane. Rapidly ubiquitinated by UBE2L6 and the E3 ubiquitin-protein ligase SIAH1 after autophosphorylation, leading to its proteasomal degradation.
Function Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
Protein Name Receptor-Type Tyrosine-Protein Kinase Flt3
Fl Cytokine Receptor
Fetal Liver Kinase-2
Flk-2
Fms-Like Tyrosine Kinase 3
Flt-3
Stem Cell Tyrosine Kinase 1
Stk-1
Cd Antigen Cd135
Database Links Reactome: R-HSA-109704
Reactome: R-HSA-1257604
Reactome: R-HSA-2219530
Reactome: R-HSA-5673001
Reactome: R-HSA-6811558
Reactome: R-HSA-9607240
Reactome: R-HSA-9645135
Reactome: R-HSA-9702509
Reactome: R-HSA-9702518
Reactome: R-HSA-9702569
Reactome: R-HSA-9702577
Reactome: R-HSA-9702581
Reactome: R-HSA-9702590
Reactome: R-HSA-9702596
Reactome: R-HSA-9702600
Reactome: R-HSA-9702605
Reactome: R-HSA-9702614
Reactome: R-HSA-9702620
Reactome: R-HSA-9702624
Reactome: R-HSA-9702632
Reactome: R-HSA-9702636
Reactome: R-HSA-9702998
Reactome: R-HSA-9703009
Reactome: R-HSA-9703648
Reactome: R-HSA-9706369
Reactome: R-HSA-9706374
Reactome: R-HSA-9706377
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Endoplasmic Reticulum Lumen
Constitutively Activated Mutant Forms With Internal Tandem Duplications Are Less Efficiently Transported To The Cell Surface And A Significant Proportion Is Retained In An Immature Form In The Endoplasmic Reticulum Lumen
The Activated Kinase Is Rapidly Targeted For Degradation
Alternative Antibody Names Anti-Receptor-Type Tyrosine-Protein Kinase Flt3 antibody
Anti-Fl Cytokine Receptor antibody
Anti-Fetal Liver Kinase-2 antibody
Anti-Flk-2 antibody
Anti-Fms-Like Tyrosine Kinase 3 antibody
Anti-Flt-3 antibody
Anti-Stem Cell Tyrosine Kinase 1 antibody
Anti-Stk-1 antibody
Anti-Cd Antigen Cd135 antibody
Anti-FLT3 antibody
Anti-CD135 antibody
Anti-FLK2 antibody
Anti-STK1 antibody

Information sourced from Uniprot.org

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