• Western blot analysis of lysates from Jurkat and COLO205 cells, using FKRP Antibody. The lane on the right is blocked with the synthesized peptide.

Anti-FKRP antibody (1-50 aa) (STJ93080)

SKU:
STJ93080

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Ribitol 5-phosphate transferase FKRP (1-50 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FKRP
Gene ID: 79147
Uniprot ID: FKRP_HUMAN
Immunogen Region: 1-50 aa
Specificity: FKRP Polyclonal Antibody detects endogenous levels of FKRP protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human FKRP at the amino acid range 1-50
Post Translational Modifications N-glycosylated.
Function Catalyzes the transfer of a ribitol 5-phosphate from CDP-L-ribitol to the ribitol 5-phosphate previously attached by FKTN/fukutin to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the second step in the formation of the ribose 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1.
Protein Name Ribitol 5-Phosphate Transferase Fkrp
Fukutin-Related Protein
Ribitol-5-Phosphate Transferase
Cellular Localisation Golgi Apparatus Membrane
Single-Pass Type Ii Membrane Protein
Secreted
Cell Membrane
Sarcolemma
Rough Endoplasmic Reticulum
Cytoplasm
According To Some Studies The N-Terminal Hydrophobic Domain Is Cleaved After Translocation To The Golgi Apparatus And The Protein Is Secreted
Localization At The Cell Membrane May Require The Presence Of Dystroglycan
At The Golgi Apparatus Localizes To The Middle-To-Trans-Cisternae
As Assessed By Mg160 Colocalization
Detected In Rough Endoplasmic Reticulum In Myocytes
In General
Mutants Associated With Severe Clinical Phenotypes Are Retained Within The Endoplasmic Reticulum
Alternative Antibody Names Anti-Ribitol 5-Phosphate Transferase Fkrp antibody
Anti-Fukutin-Related Protein antibody
Anti-Ribitol-5-Phosphate Transferase antibody
Anti-FKRP antibody

Information sourced from Uniprot.org

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