Anti-FKBP38 antibody [R05-3U6] (STJA0037350)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human FKBP38
General Information
| Short Description | Rabbit monoclonal anti-FKBP38 for use in WB, ICC, IF and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF/FC |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R05-3U6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | FKBP8 |
| Gene ID | 23770 |
| Uniprot ID | FKBP8_HUMAN |
| Immunogen | A synthesized peptide derived from human FKBP38 |
Additional Info
| Tissue Specificity | Widely expressed. Highest levels seen in the brain. Highly abundant in the retina. |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV). |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp8Ppiase Fkbp838 Kda Fk506-Binding Protein38 Kda FkbpFkbp-38Hfkbp38Fk506-Binding Protein 8Fkbp-8Fkbpr38Rotamase |
| Database Links | Reactome: R-HSA-5689880 |
| Cellular Localisation | MitochondrionMitochondrion MembraneSingle-Pass Membrane ProteinCytoplasmic SideIsoform 1: Mitochondrion MembraneIsoform 3: Mitochondrion Membrane |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase Fkbp8 antibodyAnti-Ppiase Fkbp8 antibodyAnti-38 Kda Fk506-Binding Protein antibodyAnti-38 Kda Fkbp antibodyAnti-Fkbp-38 antibodyAnti-Hfkbp38 antibodyAnti-Fk506-Binding Protein 8 antibodyAnti-Fkbp-8 antibodyAnti-Fkbpr38 antibodyAnti-Rotamase antibodyAnti-FKBP8 antibodyAnti-FKBP38 antibody |
Information sourced from Uniprot.org