Anti-FILIP1L antibody (1-200) (STJ119873)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FILIP1L (1-200) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FILIP1L |
| Gene ID | 11259 |
| Uniprot ID | FIL1L_HUMAN |
| Immunogen Region | 1-200 |
| Immunogen Sequence | MRSRGSDTEGSAQKKFPRHT KGHSFQGPKNMKHRQQDKDS PSESDVILPCPKAEKPHSGN GHQAEDLSRDDLLFLLSILE GELQARDEVIGILKAEKMDL ALLEAQYGFVTPKKVLEALQ RDAFQAKSTPWQEDIYEKPM NELDKVVEKHKESYRRILGQ LLVAEKSRRQTILELEEEKR KHKEYMEKSDEFICLLEQEC |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human FILIP1L (NP_878913.2). |
Additional Info
| Tissue Specificity | Expressed in endothelial cells, colon and colon cancers. In the colon, expressed in the vasculature and muscularis mucosa. In colon cancer, strongly expressed in tumor stroma and the vasculature (at protein level). Expressed in ovarian epithelial cells. Down-regulated in ovarian cancer. |
| Function | Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature. |
| Protein Name | Filamin A-Interacting Protein 1-Like130 Kda Gpbp-Interacting Protein90 Kda Gpbp-Interacting ProteinProtein Down-Regulated In Ovarian Cancer 1Doc-1 |
| Database Links | |
| Cellular Localisation | CytoplasmMembraneNucleus |
| Alternative Antibody Names | Anti-Filamin A-Interacting Protein 1-Like antibodyAnti-130 Kda Gpbp-Interacting Protein antibodyAnti-90 Kda Gpbp-Interacting Protein antibodyAnti-Protein Down-Regulated In Ovarian Cancer 1 antibodyAnti-Doc-1 antibodyAnti-FILIP1L antibodyAnti-COL4A3BPIP antibodyAnti-DOC1 antibodyAnti-GIP90 antibody |
Information sourced from Uniprot.org