| Tissue Specificity | Expressed in skin fibroblasts (at protein level). Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes. |
| Post Translational Modifications | N-glycosylated. |
| Function | Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. |
| Protein Name | Fibulin-5Fibl-5Developmental Arteries And Neural Crest Egf-Like ProteinDanceUrine P50 ProteinUp50 |
| Database Links | Reactome: R-HSA-1566948Reactome: R-HSA-2129379 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixCo-Localizes With Eln In Elastic Fibers |
| Alternative Antibody Names | Anti-Fibulin-5 antibodyAnti-Fibl-5 antibodyAnti-Developmental Arteries And Neural Crest Egf-Like Protein antibodyAnti-Dance antibodyAnti-Urine P50 Protein antibodyAnti-Up50 antibodyAnti-FBLN5 antibodyAnti-DANCE antibodyAnti-UNQ184 antibodyAnti-PRO210 antibody |
Information sourced from Uniprot.org
