Anti-Fibrin antibody [59D8] (STJA0019195)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
General Information
| Short Description | Mouse monoclonal Fibrinogen Beta Chain Cleaved Into-Fibrinopeptide B-Fibrinogen Beta Chain antibody for use in IF, IHC, RIA and WB in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/IHC/RIA/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 59D8 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1.97 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | FGB |
| Gene ID | 2244 |
| Uniprot ID | FIBB_HUMAN |
Additional Info
| Post Translational Modifications | Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. |
| Function | Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. |
| Protein Name | Fibrinogen Beta Chain Cleaved Into - Fibrinopeptide B - Fibrinogen Beta Chain |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-1236974Reactome: R-HSA-140875Reactome: R-HSA-166058Reactome: R-HSA-216083Reactome: R-HSA-354192Reactome: R-HSA-354194Reactome: R-HSA-372708Reactome: R-HSA-5602498Reactome: R-HSA-5603041Reactome: R-HSA-5674135Reactome: R-HSA-5686938Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Fibrinogen Beta Chain Cleaved Into - Fibrinopeptide B - Fibrinogen Beta Chain antibodyAnti-FGB antibody |
Information sourced from Uniprot.org