| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-FGF13 (2-50 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | FGF13 |
| Gene ID: | 2258 |
| Uniprot ID: | FGF13_HUMAN |
| Immunogen Region: | 2-50 aa |
| Specificity: | Specific for FGF13. |
| Immunogen: | A synthetic peptide from aa region 2-50 of mouse FGF13 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in human and rat. |
| Post Translational Modifications | May be phosphorylated. |
| Function | Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. Regulates voltage-gated sodium channel transport and function. May also play a role in MAPK signaling. Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons. |
| Protein Name | Fibroblast Growth Factor 13 Fgf-13 Fibroblast Growth Factor Homologous Factor 2 Fhf-2 |
| Database Links | Reactome: R-HSA-5576892 |
| Cellular Localisation | Isoform 1: Nucleus Isoform 2: Cytoplasm Nucleus Isoform 3: Cytoplasm Isoform 4: Cytoplasm Isoform 5: Cytoplasm Cell Projection Filopodium Growth Cone Dendrite Cell Membrane Sarcolemma Cytoplasm Not Secreted Localizes To The Lateral Membrane And Intercalated Disks Of Myocytes |
| Alternative Antibody Names | Anti-Fibroblast Growth Factor 13 antibody Anti-Fgf-13 antibody Anti-Fibroblast Growth Factor Homologous Factor 2 antibody Anti-Fhf-2 antibody Anti-FGF13 antibody Anti-FHF2 antibody |
Information sourced from Uniprot.org