| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:100 IF/ICC:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FGD1 |
| Gene ID: | 2245 |
| Uniprot ID: | FGD1_HUMAN |
| Immunogen Region: | 700-800 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 700-800 of human FGD1 (NP_004454.2). |
| Immunogen Sequence: | LLNSTNREDEDTPPNSPNVD LGKRAPTPIREKEVTMCMRC QEPFNSITKRRHHCKACGHV VCGKCSEFRARLVYDNNRSN RVCTDCYVALHGVPGSSPAC S |
| Tissue Specificity | Expressed in fetal heart, brain, lung, kidney and placenta. Less expressed in liver.adult heart, brain, lung, pancreas and skeletal muscle. |
| Function | Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. |
| Protein Name | Fyve - Rhogef And Ph Domain-Containing Protein 1 Faciogenital Dysplasia 1 Protein Rho/Rac Guanine Nucleotide Exchange Factor Fgd1 Rho/Rac Gef Zinc Finger Fyve Domain-Containing Protein 3 |
| Database Links | Reactome: R-HSA-193648 Reactome: R-HSA-416482 Reactome: R-HSA-9013148 |
| Cellular Localisation | Cytoplasm Cell Projection Lamellipodium Ruffle Cytoskeleton Associated With Membrane Ruffles And Lamellipodia |
| Alternative Antibody Names | Anti-Fyve - Rhogef And Ph Domain-Containing Protein 1 antibody Anti-Faciogenital Dysplasia 1 Protein antibody Anti-Rho/Rac Guanine Nucleotide Exchange Factor Fgd1 antibody Anti-Rho/Rac Gef antibody Anti-Zinc Finger Fyve Domain-Containing Protein 3 antibody Anti-FGD1 antibody Anti-FGDY antibody Anti-ZFYVE3 antibody |
Information sourced from Uniprot.org