• Western blot analysis of lysates from HUVEC cells, treated with serum 20% 30', using FES Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of the lysates from HUVECcells using FES antibody.
  • Western blot analysis of various cells using Fes Polyclonal Antibody

Anti-FES antibody (131-180 aa) (STJ93058)

SKU:
STJ93058

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Tyrosine-protein kinase Fes/Fps (131-180 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FES
Gene ID: 2242
Uniprot ID: FES_HUMAN
Immunogen Region: 131-180 aa
Specificity: Fes Polyclonal Antibody detects endogenous levels of Fes protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human FES at the amino acid range 131-180
Post Translational Modifications Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK.
Function Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.
Protein Name Tyrosine-Protein Kinase Fes/Fps
Feline Sarcoma/Fujinami Avian Sarcoma Oncogene Homolog
Proto-Oncogene C-Fes
Proto-Oncogene C-Fps
P93c-Fes
Database Links Reactome: R-HSA-1433557
Reactome: R-HSA-399954
Reactome: R-HSA-399955
Reactome: R-HSA-399956
Cellular Localisation Cytoplasm
Cytosol
Cytoskeleton
Cell Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cytoplasmic Vesicle
Golgi Apparatus
Cell Junction
Focal Adhesion
Distributed Throughout The Cytosol When The Kinase Is Not Activated
Association With Microtubules Requires Activation Of The Kinase Activity
Shuttles Between Focal Adhesions And Cell-Cell Contacts In Epithelial Cells
Recruited To The Lateral Cell Membrane In Polarized Epithelial Cells By Interaction With Phosphorylated Ezr
Detected At Tubular Membrane Structures In The Cytoplasm And At The Cell Periphery
Alternative Antibody Names Anti-Tyrosine-Protein Kinase Fes/Fps antibody
Anti-Feline Sarcoma/Fujinami Avian Sarcoma Oncogene Homolog antibody
Anti-Proto-Oncogene C-Fes antibody
Anti-Proto-Oncogene C-Fps antibody
Anti-P93c-Fes antibody
Anti-FES antibody
Anti-FPS antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance