Anti-FERMT2 antibody [14A11] (STJA0032612)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
ImmunogenFull length human recombinant protein of human FERMT2 produced in 293T cell.
General Information
| Short Description | Mouse monoclonal anti-FERMT2 for use in WB, IHC-P, ICC and IF in Human, Monkey, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Mouse |
| Reactivity | Human/Monkey/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 14A11 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100ICC 1:100-1:200 |
| Formulation | Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | FERMT2 |
| Gene ID | 10979 |
| Uniprot ID | FERM2_HUMAN |
| Immunogen | Full length human recombinant protein of human FERMT2 produced in 293T cell. |
Additional Info
| Tissue Specificity | Ubiquitous. Found in numerous tumor tissues. |
| Function | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading.this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. |
| Protein Name | Fermitin Family Homolog 2Kindlin-2Mitogen-Inducible Gene 2 ProteinMig-2Pleckstrin Homology Domain-Containing Family C Member 1Ph Domain-Containing Family C Member 1 |
| Database Links | Reactome: R-HSA-446353Reactome: R-HSA-9013149Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmCell CortexCytoskeletonStress FiberCell JunctionFocal AdhesionMembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionLamellipodium MembraneNucleusMyofibrilSarcomereI BandCell SurfaceColocalizes With Actin Stress Fibers At Cell-Ecm Focal Adhesion SitesColocalizes With Itgb3 At Lamellipodia At The Leading Edge Of Spreading CellsBinds To Membranes That Contain Phosphatidylinositides |
| Alternative Antibody Names | Anti-Fermitin Family Homolog 2 antibodyAnti-Kindlin-2 antibodyAnti-Mitogen-Inducible Gene 2 Protein antibodyAnti-Mig-2 antibodyAnti-Pleckstrin Homology Domain-Containing Family C Member 1 antibodyAnti-Ph Domain-Containing Family C Member 1 antibodyAnti-FERMT2 antibodyAnti-KIND2 antibodyAnti-MIG2 antibodyAnti-PLEKHC1 antibody |
Information sourced from Uniprot.org