Anti-FER antibody [5D2C4] (STJ98064)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant fragment of human Fer expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-Tyrosine-protein kinase Fer for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Mouse |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 5D2C4 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000IHC 1:200-1:1000IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FER |
| Gene ID | 2241 |
| Uniprot ID | FER_HUMAN |
| Immunogen | Purified recombinant fragment of human Fer expressed in E. Coli. |
| Specificity | Fer Monoclonal Antibody detects endogenous levels of Fer protein. |
Additional Info
| Post Translational Modifications | Autophosphorylated. Polyubiquitinated.this leads to proteasomal degradation. |
| Function | Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. |
| Protein Name | Tyrosine-Protein Kinase FerFeline Encephalitis Virus-Related Kinase FerFujinami Poultry Sarcoma/Feline Sarcoma-Related Protein FerProto-Oncogene C-FerTyrosine Kinase 3P94-Fer |
| Database Links | Reactome: R-HSA-1433557 |
| Cellular Localisation | CytoplasmCytoskeletonCell MembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionCell JunctionMembraneNucleusCell CortexAssociated With The ChromatinDetected On Microtubules In Polarized And Motile Vascular Endothelial CellsColocalizes With F-Actin At The Cell CortexColocalizes With Pecam1 And Ctnnd1 At Nascent Cell-Cell Contacts |
| Alternative Antibody Names | Anti-Tyrosine-Protein Kinase Fer antibodyAnti-Feline Encephalitis Virus-Related Kinase Fer antibodyAnti-Fujinami Poultry Sarcoma/Feline Sarcoma-Related Protein Fer antibodyAnti-Proto-Oncogene C-Fer antibodyAnti-Tyrosine Kinase 3 antibodyAnti-P94-Fer antibodyAnti-FER antibodyAnti-TYK3 antibody |
Information sourced from Uniprot.org