| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FER (200-450) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FER |
| Gene ID: |
2241 |
| Uniprot ID: |
FER_HUMAN |
| Immunogen Region: |
200-450 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 200-450 of human FER (NP_005237.2). |
| Immunogen Sequence: |
YDITLPLLLDSLQKMQEEMI KALKGIFDEYSQITSLVTEE IVNVHKEIQMSVEQIDPSTE YNNFIDVHRTTAAKEQEIEF DTSLLEENENLQANEIMWNN LTAESLQVMLKTLAEELMQT QQMLLNKEEAVLELEKRIEE SSETCEKKSDIVLLLSQKQA LEELKQSVQQLRCTEAKFSA QKELLEQKVQENDGKEPPPV VNYEEDARSVTSMERKERLS KFESIRHSIAGIIRSPKSA |
| Tissue Specificity | Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed. |
| Post Translational Modifications | Autophosphorylated. Polyubiquitinated.this leads to proteasomal degradation. |
| Function | Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus. |
| Protein Name | Tyrosine-Protein Kinase FerFeline Encephalitis Virus-Related Kinase FerFujinami Poultry Sarcoma/Feline Sarcoma-Related Protein FerProto-Oncogene C-FerTyrosine Kinase 3P94-Fer |
| Database Links | Reactome: R-HSA-1433557 |
| Cellular Localisation | CytoplasmCytoskeletonCell MembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionCell JunctionMembraneNucleusCell CortexAssociated With The ChromatinDetected On Microtubules In Polarized And Motile Vascular Endothelial CellsColocalizes With F-Actin At The Cell CortexColocalizes With Pecam1 And Ctnnd1 At Nascent Cell-Cell Contacts |
| Alternative Antibody Names | Anti-Tyrosine-Protein Kinase Fer antibodyAnti-Feline Encephalitis Virus-Related Kinase Fer antibodyAnti-Fujinami Poultry Sarcoma/Feline Sarcoma-Related Protein Fer antibodyAnti-Proto-Oncogene C-Fer antibodyAnti-Tyrosine Kinase 3 antibodyAnti-P94-Fer antibodyAnti-FER antibodyAnti-TYK3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
