| Short Description : | Rabbit monoclonal Farnesyl Pyrophosphate Synthase (320-419) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4093RM |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FDPS |
| Gene ID: | 2224 |
| Uniprot ID: | FPPS_HUMAN |
| Immunogen Region: | 320-419 |
| Immunogen Sequence: | VTGKIGTDIQDNKCSWLVVQ CLQRATPEQYQILKENYGQK EAEKVARVKALYEELDLPAV FLQYEEDSYSHIMALIEQYA APLPPAVFLGLARKIYKRRK |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 320-419 of human FPS/FDPS (P14324). |
| Function | Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. |
| Protein Name | Farnesyl Pyrophosphate SynthaseFpp SynthaseFps(2e -6e-Farnesyl Diphosphate SynthaseDimethylallyltranstransferaseFarnesyl Diphosphate SynthaseGeranyltranstransferase |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-2426168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Farnesyl Pyrophosphate Synthase antibodyAnti-Fpp Synthase antibodyAnti-Fps antibodyAnti-(2e -6e-Farnesyl Diphosphate Synthase antibodyAnti-Dimethylallyltranstransferase antibodyAnti-Farnesyl Diphosphate Synthase antibodyAnti-Geranyltranstransferase antibodyAnti-FDPS antibodyAnti-FPS antibodyAnti-KIAA1293 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and MEK7 knockout (KO) 293T (KO) cells, using [KO Validated] MEK7 Rabbit monoclonal antibody (STJ11101420) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/90333/359601/STJ11101420_1__46027.1713124092.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and MEK7 knockout (KO) 293T (KO) cells, using [KO Validated] MEK7 Rabbit monoclonal antibody (STJ11101420) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.")
