Anti-FCRL1 antibody (C-Term) (STJ73124)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-FCRL1 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 55+48kDa bands observed in Human Tonsil and Thymus lysates (calculated MW of 46.9kDa according to NP_443170.1). The observed molecular weights correspond to the glycosylated for |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | FCRL1 |
| Gene ID | 115350 |
| Uniprot ID | FCRL1_HUMAN |
| Accession Number | NP_443170.1; NP_001152870.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | SRLRKANITDVD |
| Specificity | This antibody is expected to recognize isoform 1 (NP_443170.1) and isoform 3 (NP_001152870.1). |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosines upon activation. |
| Function | Type I transmembrane surface glycoprotein preferentially expressed by B-cells that regulates BCR-mediated signaling responses. Recruits ABL1 as the intracellular effector molecule to enhance B-cell activation. Plays also a negative role by suppressing ERK activation under homeostatic and BCR-stimulated conditions in a GRB2-dependent manner. |
| Protein Name | Fc Receptor-Like Protein 1Fcr-Like Protein 1Fcrl1Fc Receptor Homolog 1Fcrh1Ifgp Family Protein 1Hifgp1Immune Receptor Translocation-Associated Protein 5Cd Antigen Cd307a |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Fc Receptor-Like Protein 1 antibodyAnti-Fcr-Like Protein 1 antibodyAnti-Fcrl1 antibodyAnti-Fc Receptor Homolog 1 antibodyAnti-Fcrh1 antibodyAnti-Ifgp Family Protein 1 antibodyAnti-Hifgp1 antibodyAnti-Immune Receptor Translocation-Associated Protein 5 antibodyAnti-Cd Antigen Cd307a antibodyAnti-FCRL1 antibodyAnti-FCRH1 antibodyAnti-IFGP1 antibodyAnti-IRTA5 antibody |
Information sourced from Uniprot.org