| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-CD23 (222-321) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S0MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FCER2 |
| Gene ID: |
2208 |
| Uniprot ID: |
FCER2_HUMAN |
| Immunogen Region: |
222-321 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 222-321 of human CD23 (P06734). |
| Immunogen Sequence: |
GLRNLDLKGEFIWVDGSHVD YSNWAPGEPTSRSQGEDCVM MRGSGRWNDAFCDRKLGAWV CDRLATCTPPASEGSAESMG PDSRPDPDGRLPTPSAPLHS |
| Post Translational Modifications | N- and O-glycosylated. The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding. |
| Function | Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells. On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway. |
| Protein Name | Low Affinity Immunoglobulin Epsilon Fc ReceptorBlast-2C-Type Lectin Domain Family 4 Member JFc-Epsilon-RiiImmunoglobulin E-Binding FactorLymphocyte Ige ReceptorCd Antigen Cd23 Cleaved Into - Low Affinity Immunoglobulin Epsilon Fc Receptor Membrane-Bound Form - Low Affinity Immunoglobulin Epsilon Fc Receptor Soluble Form |
| Database Links | Reactome: R-HSA-2197563Reactome: R-HSA-6783783Reactome: R-HSA-6785807 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinLipid-AnchorSecretedAlso Exists As A Soluble Excreted FormScd23 |
| Alternative Antibody Names | Anti-Low Affinity Immunoglobulin Epsilon Fc Receptor antibodyAnti-Blast-2 antibodyAnti-C-Type Lectin Domain Family 4 Member J antibodyAnti-Fc-Epsilon-Rii antibodyAnti-Immunoglobulin E-Binding Factor antibodyAnti-Lymphocyte Ige Receptor antibodyAnti-Cd Antigen Cd23 Cleaved Into - Low Affinity Immunoglobulin Epsilon Fc Receptor Membrane-Bound Form - Low Affinity Immunoglobulin Epsilon Fc Receptor Soluble Form antibodyAnti-FCER2 antibodyAnti-CD23A antibodyAnti-CLEC4J antibodyAnti-FCE2 antibodyAnti-IGEBF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
