| Host: | Armenian Hamster |
| Applications: | FC |
| Reactivity: | Mouse |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | Armenian Hamster monoclonal antibody anti-High affinity immunoglobulin epsilon receptor subunit alpha is suitable for use in Flow Cytometry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | MAR-1 |
| Conjugation: | APC |
| Isotype: | IgG |
| Formulation: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Concentration: | 0.2 mg/mL |
| Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
| Gene Symbol: | Fcer1a |
| Gene ID: | 14125 |
| Uniprot ID: | FCERA_MOUSE |
| Tissue Specificity | Expressed in bone marrow mast cells, as well as in the pineal gland at night. |
| Function | High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions. |
| Protein Name | High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha Fc-Epsilon Ri-Alpha Fceri Ige Fc Receptor Subunit Alpha |
| Database Links | Reactome: R-MMU-2454202 Reactome: -MMU-2730905 Reactome: -MMU-2871796 Reactome: -MMU-2871809 Reactome: -MMU-2871837 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha antibody Anti-Fc-Epsilon Ri-Alpha antibody Anti-Fceri antibody Anti-Ige Fc Receptor Subunit Alpha antibody Anti-Fcer1a antibody Anti-Fce1a antibody |
Information sourced from Uniprot.org