| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FBXO22 |
| Gene ID: | 26263 |
| Uniprot ID: | FBX22_HUMAN |
| Immunogen Region: | 104-403 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 104-403 of human FBXO22 (NP_671717.1). |
| Immunogen Sequence: | YMADSETFISLEECRGHKRA RKRTSMETALALEKLFPKQC QVLGIVTPGIVVTPMGSGSN RPQEIEIGESGFALLFPQIE GIKIQPFHFIKDPKNLTLER HQLTEVGLLDNPELRVVLVF GYNCCKVGASNYLQQVVSTF SDMNIILAGGQVDNLSSLTS EKNPLDIDASGVVGLSFSGH RIQSATVLLNEDVSDEKTAE AAMQRLKAANIPEHNTIGFM FACVGRGFQYYRAKGNVEA |
| Tissue Specificity | Predominantly expressed in liver, also enriched in cardiac muscle. |
| Function | Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. |
| Protein Name | F-Box Only Protein 22 F-Box Protein Fbx22p44 |
| Database Links | Reactome: R-HSA-8951664 Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm Myofibril Sarcomere Z Line |
| Alternative Antibody Names | Anti-F-Box Only Protein 22 antibody Anti-F-Box Protein Fbx22p44 antibody Anti-FBXO22 antibody Anti-FBX22 antibody |
Information sourced from Uniprot.org