| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
FBXL7 |
| Gene ID: |
23194 |
| Uniprot ID: |
FBXL7_HUMAN |
| Immunogen Region: |
1-180 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human FBXL7 (NP_036436.1). |
| Immunogen Sequence: |
MGANNGKQYGSEGKGSSSIS SDVSSSTDHTPTKAQKNVAT SEDSDLSMRTLSTPSPALIC PPNLPGFQNGRGSSTSSSSI TGETVAMVHSPPPTRLTHPL IRLASRPQKEQASIDRLPDH SMVQIFSFLPTNQLCRCARV CRRWYNLAWDPRLWRTIRLT GETINVDRALKVLTRRLCQD |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest. It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5. |
| Protein Name | F-Box/Lrr-Repeat Protein 7F-Box And Leucine-Rich Repeat Protein 7F-Box Protein Fbl6/Fbl7 |
| Database Links | Reactome: R-HSA-8854050Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeLocalizes To The Centrosome During Spindle Formation |
| Alternative Antibody Names | Anti-F-Box/Lrr-Repeat Protein 7 antibodyAnti-F-Box And Leucine-Rich Repeat Protein 7 antibodyAnti-F-Box Protein Fbl6/Fbl7 antibodyAnti-FBXL7 antibodyAnti-FBL6 antibodyAnti-FBL7 antibodyAnti-KIAA0840 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
