| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | FBXL7 |
| Gene ID: | 23194 |
| Uniprot ID: | FBXL7_HUMAN |
| Immunogen Region: | 1-180 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human FBXL7 (NP_036436.1). |
| Immunogen Sequence: | MGANNGKQYGSEGKGSSSIS SDVSSSTDHTPTKAQKNVAT SEDSDLSMRTLSTPSPALIC PPNLPGFQNGRGSSTSSSSI TGETVAMVHSPPPTRLTHPL IRLASRPQKEQASIDRLPDH SMVQIFSFLPTNQLCRCARV CRRWYNLAWDPRLWRTIRLT GETINVDRALKVLTRRLCQD |
| Function | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest. It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5. |
| Protein Name | F-Box/Lrr-Repeat Protein 7 F-Box And Leucine-Rich Repeat Protein 7 F-Box Protein Fbl6/Fbl7 |
| Database Links | Reactome: R-HSA-8854050 Reactome: R-HSA-8951664 Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm Cytoskeleton Microtubule Organizing Center Centrosome Localizes To The Centrosome During Spindle Formation |
| Alternative Antibody Names | Anti-F-Box/Lrr-Repeat Protein 7 antibody Anti-F-Box And Leucine-Rich Repeat Protein 7 antibody Anti-F-Box Protein Fbl6/Fbl7 antibody Anti-FBXL7 antibody Anti-FBL6 antibody Anti-FBL7 antibody Anti-KIAA0840 antibody |
Information sourced from Uniprot.org