| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
FBXL3 |
| Gene ID: |
26224 |
| Uniprot ID: |
FBXL3_HUMAN |
| Immunogen Region: |
1-110 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human FBXL3 (NP_036290.1). |
| Immunogen Sequence: |
MKRGGRDSDRNSSEEGTAEK SKKLRTTNEHSQTCDWGNLL QDIILQVFKYLPLLDRAHAS QVCRNWNQVFHMPDLWRCFE FELNQPATSYLKATHPELIK QIIKRHSNHL |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Undergoes autophagy-mediated degradation in the liver in a time-dependent manner. |
| Function | Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. |
| Protein Name | F-Box/Lrr-Repeat Protein 3F-Box And Leucine-Rich Repeat Protein 3aF-Box/Lrr-Repeat Protein 3a |
| Database Links | Reactome: R-HSA-390471Reactome: R-HSA-400253Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusCytoplasmPredominantly Nuclear |
| Alternative Antibody Names | Anti-F-Box/Lrr-Repeat Protein 3 antibodyAnti-F-Box And Leucine-Rich Repeat Protein 3a antibodyAnti-F-Box/Lrr-Repeat Protein 3a antibodyAnti-FBXL3 antibodyAnti-FBL3A antibodyAnti-FBXL3A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
