| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-FAPP2/PLEKHA8 (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-Recommended concentration, 2-4µg/mlELISA-antibody detection limit dilution 1:64000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
PLEKHA8 |
| Gene ID: |
84725 |
| Uniprot ID: |
PKHA8_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_116028.1 |
| Immunogen Sequence: |
DIQTALRNPTENT |
| Function | Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. |
| Protein Name | Pleckstrin Homology Domain-Containing Family A Member 8Ph Domain-Containing Family A Member 8Phosphatidylinositol-Four-Phosphate Adapter Protein 2Fapp-2Phosphoinositol 4-Phosphate Adapter Protein 2Hfapp2Serologically Defined Breast Cancer Antigen Ny-Br-86 |
| Database Links | Reactome: R-HSA-1660499 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembraneMembranePeripheral Membrane ProteinBinds Through Its Ph Domain To Ptdins(4)P And Arf1And Subsequently Localizes To Tgn Exit Sites |
| Alternative Antibody Names | Anti-Pleckstrin Homology Domain-Containing Family A Member 8 antibodyAnti-Ph Domain-Containing Family A Member 8 antibodyAnti-Phosphatidylinositol-Four-Phosphate Adapter Protein 2 antibodyAnti-Fapp-2 antibodyAnti-Phosphoinositol 4-Phosphate Adapter Protein 2 antibodyAnti-Hfapp2 antibodyAnti-Serologically Defined Breast Cancer Antigen Ny-Br-86 antibodyAnti-PLEKHA8 antibodyAnti-FAPP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
