| Post Translational Modifications | N-glycosylation is required for folding. Autophosphorylated. Propeptide cleavage by MBTPS1/S1P promotes FAM20C secretion and maximal kinase activity which is essential for efficient osteoblast differentiation and biomineralization. |
| Function | Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome. Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity. Phosphorylates ERO1A, enhancing its activity which is required to maintain endoplasmic reticulum redox homeostasis and for oxidative protein folding. During endoplasmic reticulum stress, phosphorylates P4HB/PDIA1 which induces a functional switch, causing P4HB to change from an oxidoreductase to a molecular chaperone. This is critical to maintain ER proteostasis and reduce cell death under ER stress. Phosphorylation of P4HB also promotes its interaction with ERN1, leading to reduced activity of ERN1, a key sensor for the endoplasmic reticulum unfolded protein response. Required for osteoblast differentiation and mineralization. Phosphorylates casein as well as a number of proteins involved in biomineralization such as AMELX, AMTN, ENAM and SPP1/OPN. In addition to its role in biomineralization, also plays a role in lipid homeostasis, wound healing and cell migration and adhesion. |
| Protein Name | Extracellular Serine/Threonine Protein Kinase Fam20cDentin Matrix Protein 4Dmp-4Golgi Casein KinaseGolgi-Enriched Fraction Casein KinaseGef-Ck |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinSecretedEndoplasmic ReticulumResides In The Golgi Apparatus Membrane And Is Secreted Following Propeptide CleavageRetained In The Endoplasmic Reticulum (Er) In Response To Er Stress Where It Phosphorylates P4hb |
| Alternative Antibody Names | Anti-Extracellular Serine/Threonine Protein Kinase Fam20c antibodyAnti-Dentin Matrix Protein 4 antibodyAnti-Dmp-4 antibodyAnti-Golgi Casein Kinase antibodyAnti-Golgi-Enriched Fraction Casein Kinase antibodyAnti-Gef-Ck antibodyAnti-FAM20C antibodyAnti-DMP4 antibody |
Information sourced from Uniprot.org
