| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FAM208A (700-1000) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TASOR |
| Gene ID: |
23272 |
| Uniprot ID: |
TASOR_HUMAN |
| Immunogen Region: |
700-1000 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human FAM208A (NP_001106207.1). |
| Immunogen Sequence: |
DTEDMRSKTVLKRKLEDLPE NMRKLAKTSNLSENCHLYEE SPQPIGSLGHDADLRRQQQD TCNSGIADIHRLFNWLSETL ANARHSDASLTDTVNKALGL STDDAYEELRQKHEYELNST PDKKDYEQPTCAKVENAQFK GTQSLLLEVDATSKYSVAIS TSEVGTDHKLHLKEDPNLIS VNNFEDCSLCPSVPIEHGFR RQQSKSNNVEETEIHWKLIP ITGGNARSPEDQLGKHGEK |
| Function | Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. Plays a crucial role in early embryonic development. Involved in the organization of spindle poles and spindle apparatus assembly during zygotic division. Plays an important role in maintaining epiblast fitness or potency. |
| Protein Name | Protein TasorCtcl Tumor Antigen Se89-1Retinoblastoma-Associated Protein Rap140Transgene Activation Suppressor Protein |
| Cellular Localisation | NucleusChromosomeLocalizes To Chromatin |
| Alternative Antibody Names | Anti-Protein Tasor antibodyAnti-Ctcl Tumor Antigen Se89-1 antibodyAnti-Retinoblastoma-Associated Protein Rap140 antibodyAnti-Transgene Activation Suppressor Protein antibodyAnti-TASOR antibodyAnti-C3orf63 antibodyAnti-FAM208A antibodyAnti-KIAA1105 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
