| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Acyl-CoA-desaturase fatty acid desaturase desaturase is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FADS1 |
| Gene ID: | 3992 |
| Uniprot ID: | FADS1_HUMAN |
| Specificity: | This antibody detects endogenous levels of FADS1 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human FADS1 |
| Function | Isoform 1: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively. As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells. Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6). Isoform 2: Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity. |
| Protein Name | Acyl-Coa 8-3-Desaturase Delta(5 Fatty Acid Desaturase D5d Delta(5 Desaturase Delta-5 Desaturase Fatty Acid Desaturase 1 |
| Database Links | Reactome: R-HSA-1989781 Reactome: R-HSA-2046105 Reactome: R-HSA-2046106 |
| Cellular Localisation | Isoform 1: Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Mitochondrion Isoform 2: Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Acyl-Coa antibody Anti-8-3-Desaturase antibody Anti-Delta(5 Fatty Acid Desaturase antibody Anti-D5d antibody Anti-Delta(5 Desaturase antibody Anti-Delta-5 Desaturase antibody Anti-Fatty Acid Desaturase 1 antibody Anti-FADS1 antibody Anti-FADSD5 antibody |
Information sourced from Uniprot.org